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    Widespread resistance of malarial parasite to drugs like chloroquine has prompted attempts to develop a malarial vaccine to combat malaria. Why is it difficult to develop an effective malaria vaccine ?

  • Malaria is caused by several species of Plasmodium
  • Man does not develop, immunity to malaria during natural infection
  • Vaccines can be developed only against bacteria
  • Man is only an intermediate host and not the definitive host

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